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1、AriskassessmentofMERS-CoVcomparedtoSARS-CoVAriskassessmentofMERS-CoVcomparedtoSARS-CoVAriskassessmentofMERS-CoVcomparedtoSARS-CoVMaartjevanGeenen(9756000)SupervisedbyDr.B.J.Boschisecondreviewer:Dr.R.J.deGrootbstractThIscenturytwonoveIcoronaviruseSappearedwithinadecade,Causingbothsevererespiratorydis
2、easeinhumans.Thesevereacuterespiratorysyndromecoronavirus(SARS-CoV),whichoriginatedinChinainNovember2002,wasthefirstcoronavirustOcauseapandemicinhmansthroughzoonotictransmissionwithal%casefatalityrate,causingapproximate1y8000victimswor1dwide.EVenthoughSARS-Covtransmissionwascontainedwithinayear,fear
3、remainedthatothercoronavirusesinzoonoticreservoirsmightalsocrossthebarriertohumansandevo1vehumantohumantransmission1ikeSRS-CoVdid.ThisfearbecamereaIityinSeptember2012,whentheMidd1eEastRespiratorySyndromeCoronavirus(MERS-CoV)wasdiscoveredinSaudiArabia,causingseverelowerrespiratOrysymptomsinhunianswit
4、hanestiniatedcasefatalItyrateof40%.BecauseofthephylogeneticrelatednessofbothvirusesandsimilaritiesinClinicalsymptomsandpathology,HriskassessmentofMERS-CoVcomparedtoSARS-CoVismade,basedontheknow1edgeavai1ab1eforbothvirusesthusfar.Thisway,abetterpreparednessfornewoutbreaksofMERS-CoVandSARS-CoVCanbCeSt
5、abIiShCdandtheriSkOfanCWPandCmiCWiththenewlydiscoveredMERS-CoVcanbeassessed.IntroductionIthasiongbeenknownthalvirusescancrossspeciesbarricrsandadaptfromanimalStohumanstosometimesevolVehumantohuinantransmission,aswasseenforsmallpox,measlesandinfluenza.Thclatter,a1socalIedtheSpanishflu,Causedapandemicbackin1918-19,killing.
