Abstract 101 Pilot study of oral microbiome and risk of pancreatic cancer.docx

上传人:p** 文档编号:469291 上传时间:2023-09-09 格式:DOCX 页数:2 大小:15.80KB
下载 相关 举报
Abstract 101 Pilot study of oral microbiome and risk of pancreatic cancer.docx_第1页
第1页 / 共2页
Abstract 101 Pilot study of oral microbiome and risk of pancreatic cancer.docx_第2页
第2页 / 共2页
亲,该文档总共2页,全部预览完了,如果喜欢就下载吧!
资源描述

《Abstract 101 Pilot study of oral microbiome and risk of pancreatic cancer.docx》由会员分享,可在线阅读,更多相关《Abstract 101 Pilot study of oral microbiome and risk of pancreatic cancer.docx(2页珍藏版)》请在第壹文秘上搜索。

1、POSTERPRESENTA11ONS-PROFFEREDABSTRACTS,APRIL152013Abstract101:Pilotstudyoforalmicrobiomeandriskofpancreaticcancer.I-HsinLin;JingWu;StevenM.Cohen;CalvinChen;DarrenBryk;MollieMarr;MarcovalerioMelis;ElliotNewman;HLeonPachter;AlexanderV.Alekseyenko;RichardB.Hayes;JiyoungAhnAuthor&ArticleInformationCance

2、rRes(2013)73(8_Supplement):101.https:/doi.Org/10.1158/1538-7445.AM2013-101 Split-Screen ShareIconShare ToolsIconTooIs ArticleVersionsIconVersionsAbstractPreviousstudiesshowedthatperiodontitisandtoothlossareassociatedwithincreasedriskofpancreaticcancer,suggestingpossibleroleoforalbacteriainthepancrea

3、ticcanceretiology.Weevaluatedwhetheroralmicrobiomeisassociatedwithriskofpancreaticcancerandpancreatitis.Oralwashsampleswerecollectedfrom13pancreaticcancerpatients,3pancreatitispatientsand12healthycontrolsatNYULangoneMedicalCenter,NewYork.Ribosomal16SrRNAgenesfromoralwashDNAwereamplifiedbyuniversalpr

4、imers,barcoded,andsequencedwith454FLXtechnology.Thebacterial16SrRNAgenesequenceswerebinnedintooperationaltaxonomicunits(OTUs)with97%identifyandfurtherclassifiedbytaxonomy.NonparametricWilcoxonMannWhiteneyUtestandKuskal-Wallistestwereconductedtocomparetherelativeabundanceoftaxaacrosspancreaticcancer,

5、pancreatitisandcontrolgroups.Atotalof250,008sequencereads(average8,928readspersample)wereobserved.Firmicutes,Bacteroidetes,andActinobacteriaaremajorphyla,accountingfor96.5%oforalmicrobiota.Wefoundthatbacteroidesgenuswassignificantlymoreabundantinbothpancreaticcancerpatients(p=0.002)andpancreatitispa

6、tients(p=0.004)comparedwithcontrolgroup.Further,BLASTsearchresultsindicatethatthespeciesmostcloselyrepresentedbytheBacteroidesOTUswereoralpathogen.Inaddition,Corynebacterium(p=0.033)andAggregatibacter(p=0.019)werelessabundantinpancreaticcancerandpancretitisgroupscomparedwithcontrols.Datafromthispilo

7、tstudyoforalmicrobiomeandpancreaticcancersuggestthatthedifferentialabundanceinbacteriodatesandpossiblyCorynebacteriumandAggregatibacter5areassociatedwithriskofpancreaticcancer.Bacteroides,Gram-negativebacillusbacteria,playsanimportantroleinoralinflammation,includingperiodontitis.Furtherlargerstudies

8、arewarrantedtoconfirmthesepreliminaryfindings.CitationFormat:I-HsinLin,JingWu,StevenM.Cohen,CalvinChen,DarrenBryk5MollieMarr,MarcovalerioMelis,ElliotNewman,HLeonPachter,AlexanderV.Alekseyenko5RichardB.Hayes,JiyoungAhn.Pilotstudyoforalmicrobiomeandriskofpancreaticcancer,abstract.In:Proceedingsofthe104thAnnualMeetingoftheAmericanAssociationforCancerResearch;2013Apr6-10;Washington,DC.Philadelphia(PA):AACR;CancerRes2013;73(8SUPPI):AbStraCtnr101.doi:10.1158/1538-7445.AM2013-101

展开阅读全文
相关资源
猜你喜欢
相关搜索

当前位置:首页 > 高等教育 > 大学课件

copyright@ 2008-2023 1wenmi网站版权所有

经营许可证编号:宁ICP备2022001189号-1

本站为文档C2C交易模式,即用户上传的文档直接被用户下载,本站只是中间服务平台,本站所有文档下载所得的收益归上传人(含作者)所有。第壹文秘仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对上载内容本身不做任何修改或编辑。若文档所含内容侵犯了您的版权或隐私,请立即通知第壹文秘网,我们立即给予删除!