《Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine.docx》由会员分享，可在线阅读，更多相关《Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine.docx（11页珍藏版）》请在第壹文秘上搜索。
1、naturecommunicationsArticlehttps:doi.org/10.1038/s41467-022-35440-wTemperature-adaptivehydrogelopticalwaveguidewithsofttissue-affinityforthermalregulatedinterventionalphotomedicineReceived: 21 January 2022Accepted: 2 December 2022Published online: 16 December 2022Check for updatesGuoyinCheni,KaiHouO
2、State Key Laboratory for Modifi cation of Chemical Fibers and Polymer Materials, College of Materials Science and Engineerinq, Donghua University, 2999 North Renmin Road, Shanghai 201620, China. iDepartment of Chemistry, Stony Brook University, Stony Brook, NewYork, NY 11794r USA.e-mail: houkai711;
3、rancao; zmf,NuoYui,PeilingWeii,TaoChem,CaihongZhangi,ShunWang,HongmeiLiu,RanCao1,LipingZhuBenjaminS.HsiaoS&MeifangZhuO1Photomedicinehasgainedgreatattentionduetoitsnontoxicity,goodselectivityandsmalltrauma.However,owingtothelimitedpenetrationoflightanddifficultmonitoringofthephoto-mediatherapies,itis
4、challengingtoapplyphotomedicaltreatmentindeeptissueastheymaydamagenormaltissues.Herein,athermalregulatedinterventionalphotomedidnebasedonatemperature-adaptivehydrogelIiber-basedopticalwaveguide(THFOW)isproposed,capableofeliminatingdeeplyseatedtumorcellswhileloweringrisksofovertemperature(causesthede
5、athofhealthycellsaroundthetumor).TheTHFOWisfabricatedbyanintegratedhomogeneous-dynamiccrosslinking-spinningmethod,andshowsaremarkablesofttissue-affinity(lowcytotoxicity,swellingstability,andsofttissue-likeYoung,smodulus).Moreover,theTHFOWshowsanexcellentlightpropagationpropertywithdifferentwavenumbe
6、rs(especially-0.32dBcm-with915nmlaserlight),andtemperature-gatedlightpropagationeffect.TheTHFOWandrelevanttherapeuticstrategyofferapromisingapplicationforintelligentphotomedicineindeepissue.Inrecentyears,asanemergingtechnology,photomedicinehasbeenusedfortreatingcancerousdiseaseswithadvantagesofsmall
7、trauma,nontoxicity,andgoodselectivity!Thetreatmentisprincipallybasedonthelight-inducedphysicalreactions(generationofheat,suchasphotothermaltherapy)-chemicalreaction(photochemicalreaction)?.,orbiologicalprocesses(optogenetic,PhOtObioIogiCaI)Gontothediseaselocationbyinducingexogenousphotosensitivereag
8、ent如.However,asthelightpenetratesonlyafewcentimetersthroughthetissue,itisdifficulttoapplyphotomedicaltreatmentindeeptissueu.Interventionaltherapyisoneofthemosteffectiveclinicaltreatmentstoreplacethedeeplyinvasivesurgicaloperations,whichreliesmainlyonanintervenedmedium(metalwire,silicaopticalfiber,et
9、c.)toimportapparatusintothedeeplyseateddiseaselocation.Andinvitroequipment(suchlikecomputedtomographyangiography,ultrasound,magneticresonance,andetc.)iscombinedtorealizediagnosisandtreatmenti4,s.Inconsequence,inthewaythatlightguidesusedforinterventionaltherapy,photomedicinecouldeffectivelysolvethepr
10、oblemoflightpenetrationthroughtissue.Althoughlight-guidessuchassilica-andpolymer-basedopticalfibershavebeenproventobefeasible,theirstiffnessandpoorbiocompatibilitymaycauseinflammationordamagetohosttissue12j6.Besides,duringphotomedicaltreatment,thephoto-inducedeffectsshouldbecontrolledinamannertoavoi
11、dthedamageofnormaltissuearoundthediseaseslocationTothisend,combiningequipmentassistedimagingtechniquewithinterventionalphotomedicaltreatmenttomonitorandguidethetherapeuticprocessisanefficientwayiu.However,thiskindoftreatmentishigh-cost,time-consumingandcomplicated.Hence,anef-fidentmethodfordynamican
12、dpreciseinsituphysiologicalmicroenvironmentalmonitoring(temperature,pH,etc.)isdesiredforguidingthephotomedicaltherapeuticprocessinacontrolledmannerunderthedeeptissue.Hydrogel-basedopticalWaveguideareidealcandidatesforusingasintervenedlight-guidesforaccurateandtargetedlightpropagationa.i9.Asamatrix,h
13、ydrogelscanbeextensivelymodifiedbymoleculardesignandrealizeenvironmentalresponses,suchastemperature,pH,andmolecularresponse”.；Inthisregard,fabricatinghydrogelopticalwaveguidewithacertaincondensedstructureandadjustableopticalproperties,couldrealizelightguidingandphysiologicalmicroenvironmentalmonitor
14、ingsimultaneously.Forexample,basedonthecoiltoglobulewinducedtransparency-opacitytransitionatthelowercriticalsolutiontemperature(LCST)1thermosensitivehydrogelscouldbeusedastemperature-dependentopticalswitches”.However,monomerswerenotpreferredforfiberformingduetoinsufficientinteraction.Furthermore,ine
15、vitablephaseseparationduringexothermicfreeradicalpolymerizationwouldinduceagglomerationofmolecularchainsorcross-linkedmicroregions,whicharedisadvantageousforfunctionalhydrogelfiberformation,thusitisdifficulttoobtainahydrogelfiberwithauniformstructure.Inthiswork,adesiredtemperature-adaptivehydrogelfi
16、ber-basedopticalwaveguide(THFOW)isfabricatedbyanintegratedhomogeneous-dynamic-crosslinking-spinningonlarge-scale.ThefabricatedTHFOWshowsanexcellentlightpropagationpropertywithdifferentwavenumbers(especially-0.32dBCm-oflightattenuationwith915nmlaserlight)andhighlysensitivetemperature-gatedlightpropagationeffect.Inaddition,athermalregulatedinterventionalphotomedicinebasedontheTHFOWisdemonstrated,capableof
