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1、氨基酸的侧链保护基团氨基酸侧链官能团保护基保护基结构式保护基脱除条件NHoArg95%TFA,30minPbf0HNNH2NHSOO90%TFA,30minOtBuOOAsp/P)-AcOH-WM;Pb(PhGlu3400HPb(PhP)-PhSiHinDCM,OAll343010-30minOAsn/90%TFA,30-60minTrtNHGlnNH290%TFA,30-60minTrtSOHg(?);Ag(?);Tl(?);CysSHAcmSNSiClPh(S0)Ph-CH33HHF(20?);Hg(?);tBuSSiClPh(SO)Ph-CH33PRSH,BuS3SStBuOtherre
2、ducingagentsO.5-l%TFAinDCM-TES(95:5),30min;MmtSOMe3%TFA,5-10minOMe5%TFA-3%TESinDCMTmobSMeOOMe,NNHis50%TFAinDCM,30minTrtNHO90%TFA,30-60minBocNOHOP)(O.1eq)-PhSiHPb(Ph343Alloc(24eq)inDCM,IOminNOH1.ys/NH2Orn1%TFAinDCM,30min;NMcHMttAcOH-TFE-DCMd:2:7)O2%水合腓inDMF,DdeNH5-10minOSer/90%TFA,30mintBuOHOThr/Tyr01-5%TFAinDCM,2-5minTrtHONTrp90%TFA,IhBocNO
