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1、大医精诚大医精诚 尚美至善尚美至善The guideline of COPD大医精诚大医精诚 尚美至善尚美至善大医精诚大医精诚 尚美至善尚美至善DEFINITION OF COPDGlobal Initiative for Chronic Obstructive Lung Disease(GOLD)WHO/NHLBI Initiative 2010“COPD is a disease state characterised by airflow limitation that is not fully reversible.The airflowlimitation is usually bo
2、th progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases”“COPD is a disease state characterised by airflow limitation that is not fully reversible.The airflowlimitation is usually both progressive and associated with an abnormal inflammatory res
3、ponse of the lungs to noxious particles or gases”大医精诚大医精诚 尚美至善尚美至善大医精诚大医精诚 尚美至善尚美至善大医精诚大医精诚 尚美至善尚美至善How to treat COPD?1.Access and Monitor Desease 2.Reduce Risk Factors 3.Manage stable COPD 4.Manage Exacerbation大医精诚大医精诚 尚美至善尚美至善Access and Monitor Desease Symtoms:Chronic cough ,Sputum，dyspnea et.Spir
4、metry(gold standard):(post bronchodilator)FEV1/FVC70%大医精诚大医精诚 尚美至善尚美至善COPD分期与分级分期与分级Thank you！大医精诚大医精诚 尚美至善尚美至善Reduce Risk Factors大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 1 Spirometry should be obtained to diagnose airflow obstruction in patients with respiratory symptoms(strong recommenda
5、tion/moderatequality evidence)Spirometry should not be used to screen for airflow obstruction in patients without respiratory symptoms(strong recommendation/moderatequality evidence)大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 2 For stable COPD patients with respiratory symptoms and FEV1 betwe
6、en 60%and 80%predicted，ACP、ACCP、ATS、and ERS suggest that treatment with inhaled bronchodialators may be used。（weak recommendation/low-quality evidence)大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 3 For stable COPD patients with respiratory symptoms and FEV1 60%predicted，ACP、ACCP、ATS、and ERS su
7、ggest that treatment with inhaled bronchodialators may be used。（strong recommendation/moderate-quality evidence)大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 4 ACP、ACCP、ATS and ERS recommend that clinicians prescribe monotherapy using either long-acting inhalede anticholinergics or long-acting
8、inhalede B-agonists for symtomatic patients with COPD and FEV1 60%predicted。cliniciians should base the choice of the specific monotherapy on patient preference、cost、adverse effect profile.（strong recommendation/moderate-quality evidence)大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 5 ACP、ACCP、
9、ATS and ERS recommend that clinicians may administer combination inhalede therapies（long-acting inhalede anticholinergics or long-acting inhalede B-agonists、inhalede corticosteroids ）for symtomatic patients with COPD and FEV1 60%predicted。.（weak recommendation/moderate-quality evidence)大医精诚大医精诚 尚美至善
10、尚美至善Manage stable COPD Recommnedation 6 ACP、ACCP、ATS and ERS recommend that clinicians should prescribe pulmonary rehabilitation for symtomatic patients with COPD and FEV1 50%predicted。（strong recommendation/moderate-quality evidence)clinicians may consider pulmonary rehabilitation for symtomatic pa
11、tients or exercise-limited patients with an FEV150%predicted。（weak recommendation/moderate-quality evidence)大医精诚大医精诚 尚美至善尚美至善Manage stable COPD Recommnedation 7 ACP、ACCP、ATS and ERS recommend that clinicians shoulde precribe continued oxygen therapiy in patient with COPD who have severe resting hypoxemia（PaO255mmHg or SaO288%.（strong recommendation/moderate-quality evidence)大医精诚大医精诚 尚美至善尚美至善
